A20 (基因)

A20
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2EQF、2EQG、2VFJ、3DKB、3OJ3、3OJ4、3VUW、3VUX、3VUY、3ZJD、3ZJE、3ZJF、3ZJG、4ZRH、4ZS5
识别号
别名	TNFAIP3；, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
外部ID	OMIM：191163 MGI：1196377 HomoloGene：4582 GeneCards：TNFAIP3
相关疾病
	红斑性狼疮、银屑病
基因位置（人类）
染色体	6号染色体
终止	137,883,312 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	18,891,405 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• DNA结合; • 半胱氨酸型肽酶活性; • 锌离子结合; • 金属离子结合; • 泛素蛋白转移酶活性; • 蛋白酶结合; • 蛋白质自缔合; • 肽酶活性; • 连接酶活性; • 激酶结合; • K63连接的多聚泛素修饰依赖性蛋白结合; • 泛素结合; • 血浆蛋白结合; • 催化活性; • 巯基依赖性泛素特异性蛋白酶活性; • 水解酶活性; • 相同蛋白质结合; • Lys63特异性去泛素酶活性; • 转移酶活性;
细胞组分	• 细胞质; • 细胞质基质; • 溶酶体; • 外排体; • 细胞核; • 细胞内膜结合细胞器;
生物学过程	• 生发中心形成的调控; • 肝细胞增殖的正调控; • 内皮细胞凋亡过程的负调控; • 白细胞介素-1β产生的负调控; • 平滑肌细胞增殖的负调控; • 血管创伤愈合的调控; • B-1 B细胞稳态; • protein K48-linked deubiquitination; • positive regulation of protein catabolic process; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • 宿主对病毒防御反应的调控; • 泛素依赖性蛋白质分解代谢过程中的蛋白质去蛋白化; • negative regulation of toll-like receptor 2 signaling pathway; • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; • 肿瘤坏死因子介导的信号通路的调控; • negative regulation of interleukin-6 production; • negative regulation of B cell activation; • negative regulation of toll-like receptor 5 signaling pathway; • tolerance induction to lipopolysaccharide; • response to muramyl dipeptide; • negative regulation of chronic inflammatory response; • negative regulation of cell death; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • 蛋白酶解; • establishment of protein localization to vacuole; • protein deubiquitination; • negative regulation of protein ubiquitination; • protein K48-linked ubiquitination; • protein K63-linked deubiquitination; • negative regulation of CD40 signaling pathway; • 死亡域受体对外源性凋亡信号通路的负调控; • protein complex oligomerization; • protein K11-linked deubiquitination; • regulation of inflammatory response; • 含有1信号通路的核苷酸结合寡聚结构域的负调控; • negative regulation of innate immune response; • negative regulation of osteoclast proliferation; • 肿瘤坏死因子产生的负调控; • negative regulation of type I interferon production; • 代谢; • inflammatory response; • response to molecule of bacterial origin; • negative regulation of NF-kappaB transcription factor activity; • negative regulation of interleukin-2 production; • negative regulation of inflammatory response; • negative regulation of toll-like receptor 3 signaling pathway; • 含有信号通路的核苷酸结合寡聚结构域; • cellular response to lipopolysaccharide; • negative regulation of toll-like receptor 4 signaling pathway; • negative regulation of bone resorption; • cellular response to hydrogen peroxide; • 细胞凋亡; • protein ubiquitination; • 细胞骨架组织; • 细胞迁移; • positive regulation of Wnt signaling pathway; • protein K29-linked deubiquitination; • protein K33-linked deubiquitination;
	Sources:Amigo / QuickGO
直系同源
	7128
	21929
	ENSG00000118503
	ENSMUSG00000019850
	P21580
	Q60769
	NM_001270507; NM_001270508; NM_006290
	NM_001166402; NM_009397
	NP_001257436; NP_001257437; NP_006281
	NP_001159874; NP_033423
	维基数据
查看/编辑人类	查看/编辑小鼠

A20基因（或称为：肿瘤坏死因子α诱导蛋白3，英语：Tumor necrosis factor, alpha-induced protein 3，缩写TNFAIP3）是人类六号染色体上的基因^[6]^[7]，可由肿瘤坏死因子α（TNF-α）诱导表达，是一种去泛素化酶和锌指蛋白，可抑制NF-κB激活和TNF介导的细胞凋亡。A20是一种非常古老的蛋白，在刺胞动物门（水母）中也有带有同源结构域的蛋白^[8]。

蛋白质的相互作用

A20蛋白与下列蛋白质进行互作：TNIP1^[9]、TRAF1^[10]^[11]、TRAF2^[10]、IKBKG^[12]、TAX1BP1^[13]、YWHAB^[14]、YWHAZ^[14]^[15]、TRAF6^[11]^[16]和YWHAH^[14]^[15]。

参考文献

^ 與A20相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Opipari AW Jr; Boguski MS; Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.
^ Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3. （原始内容存档于2010-12-05）.
^ Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136.
^ Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471.
^ ^10.0 ^10.1 Song, H Y; Rothe M; Goeddel D V. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721.
^ ^11.0 ^11.1 Heyninck, K; Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7.
^ Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.
^ De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 .
^ ^14.0 ^14.1 ^14.2 Vincenz, C; Dixit V M. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 .
^ ^15.0 ^15.1 De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.
^ Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. Isolation and characterization of two novel A20-like proteins. Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.

外部链接

PDB中UniProt可用的所有结构信息之概述：P21580 (Tumor necrosis factor alpha-induced protein 3) 在PDBe-KB（英语：PDBe-KB）。

[1] 與A20相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2118515-6] Opipari AW Jr; Boguski MS; Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.

[entrez-7] Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3. （原始内容存档于2010-12-05）.

[8] Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136.

[pmid10385526-9] Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471.

[pmid8692885-10] 10.0 ^10.1 Song, H Y; Rothe M; Goeddel D V. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721.

[pmid9928991-11] 11.0 ^11.1 Heyninck, K; Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7.

[pmid10755617-12] Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.

[pmid10435631-13] De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 .

[pmid8702721-14] 14.0 ^14.1 ^14.2 Vincenz, C; Dixit V M. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 .

[pmid9299557-15] 15.0 ^15.1 De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.

[pmid11463333-16] Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. Isolation and characterization of two novel A20-like proteins. Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.

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