A20 (基因)

A20
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2EQF、2EQG、2VFJ、3DKB、3OJ3、3OJ4、3VUW、3VUX、3VUY、3ZJD、3ZJE、3ZJF、3ZJG、4ZRH、4ZS5
識別號
別名	TNFAIP3；, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
外部ID	OMIM：191163 MGI：1196377 HomoloGene：4582 GeneCards：TNFAIP3
相關疾病
	紅斑性狼瘡、銀屑病
基因位置（人類）
染色體	6號染色體
終止	137,883,312 bp
基因位置（小鼠）
染色體	小鼠10號染色體
終止	18,891,405 bp
RNA表達模式
	; ;
	查閱更多表達數據
基因本體
分子功能	• DNA結合; • 半胱氨酸型肽酶活性; • 鋅離子結合; • 金屬離子結合; • 泛素蛋白轉移酶活性; • 蛋白酶結合; • 蛋白質自締合; • 肽酶活性; • 連接酶活性; • 激酶結合; • K63連接的多聚泛素修飾依賴性蛋白結合; • 泛素結合; • 血漿蛋白結合; • 催化活性; • 巰基依賴性泛素特異性蛋白酶活性; • 水解酶活性; • 相同蛋白質結合; • Lys63特異性去泛素酶活性; • 轉移酶活性;
細胞組分	• 細胞質; • 細胞質基質; • 溶酶體; • 外排體; • 細胞核; • 細胞內膜結合細胞器;
生物學過程	• 生發中心形成的調控; • 肝細胞增殖的正調控; • 內皮細胞凋亡過程的負調控; • 白細胞介素-1β產生的負調控; • 平滑肌細胞增殖的負調控; • 血管創傷癒合的調控; • B-1 B細胞穩態; • protein K48-linked deubiquitination; • positive regulation of protein catabolic process; • negative regulation of cyclin-dependent protein serine/threonine kinase activity; • 宿主對病毒防禦反應的調控; • 泛素依賴性蛋白質分解代謝過程中的蛋白質去蛋白化; • negative regulation of toll-like receptor 2 signaling pathway; • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; • 腫瘤壞死因子介導的信號通路的調控; • negative regulation of interleukin-6 production; • negative regulation of B cell activation; • negative regulation of toll-like receptor 5 signaling pathway; • tolerance induction to lipopolysaccharide; • response to muramyl dipeptide; • negative regulation of chronic inflammatory response; • negative regulation of cell death; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • 蛋白酶解; • establishment of protein localization to vacuole; • protein deubiquitination; • negative regulation of protein ubiquitination; • protein K48-linked ubiquitination; • protein K63-linked deubiquitination; • negative regulation of CD40 signaling pathway; • 死亡域受體對外源性凋亡信號通路的負調控; • protein complex oligomerization; • protein K11-linked deubiquitination; • regulation of inflammatory response; • 含有1信號通路的核苷酸結合寡聚結構域的負調控; • negative regulation of innate immune response; • negative regulation of osteoclast proliferation; • 腫瘤壞死因子產生的負調控; • negative regulation of type I interferon production; • 代謝; • inflammatory response; • response to molecule of bacterial origin; • negative regulation of NF-kappaB transcription factor activity; • negative regulation of interleukin-2 production; • negative regulation of inflammatory response; • negative regulation of toll-like receptor 3 signaling pathway; • 含有信號通路的核苷酸結合寡聚結構域; • cellular response to lipopolysaccharide; • negative regulation of toll-like receptor 4 signaling pathway; • negative regulation of bone resorption; • cellular response to hydrogen peroxide; • 細胞凋亡; • protein ubiquitination; • 細胞骨架組織; • 細胞遷移; • positive regulation of Wnt signaling pathway; • protein K29-linked deubiquitination; • protein K33-linked deubiquitination;
	Sources:Amigo / QuickGO
直系同源
	7128
	21929
	ENSG00000118503
	ENSMUSG00000019850
	P21580
	Q60769
	NM_001270507; NM_001270508; NM_006290
	NM_001166402; NM_009397
	NP_001257436; NP_001257437; NP_006281
	NP_001159874; NP_033423
	維基數據
檢視/編輯人類	檢視/編輯小鼠

A20基因（或稱為：腫瘤壞死因子α誘導蛋白3，英語：Tumor necrosis factor, alpha-induced protein 3，縮寫TNFAIP3）是人類六號染色體上的基因^[6]^[7]，可由腫瘤壞死因子α（TNF-α）誘導表達，是一種去泛素化酶和鋅指蛋白，可抑制NF-κB激活和TNF介導的細胞凋亡。A20是一種非常古老的蛋白，在刺胞動物門（水母）中也有帶有同源結構域的蛋白^[8]。

蛋白質的相互作用

A20蛋白與下列蛋白質進行互作：TNIP1^[9]、TRAF1^[10]^[11]、TRAF2^[10]、IKBKG^[12]、TAX1BP1^[13]、YWHAB^[14]、YWHAZ^[14]^[15]、TRAF6^[11]^[16]和YWHAH^[14]^[15]。

參考文獻

^ 與A20相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Opipari AW Jr; Boguski MS; Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.
^ Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3. （原始內容存檔於2010-12-05）.
^ Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136.
^ Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471.
^ ^10.0 ^10.1 Song, H Y; Rothe M; Goeddel D V. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721.
^ ^11.0 ^11.1 Heyninck, K; Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7.
^ Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.
^ De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 .
^ ^14.0 ^14.1 ^14.2 Vincenz, C; Dixit V M. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 .
^ ^15.0 ^15.1 De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.
^ Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. Isolation and characterization of two novel A20-like proteins. Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.

外部連結

PDB中UniProt可用的所有結構信息之概述：P21580 (Tumor necrosis factor alpha-induced protein 3) 在PDBe-KB（英語：PDBe-KB）。

[1] 與A20相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000118503 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000019850 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2118515-6] Opipari AW Jr; Boguski MS; Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem. October 1990, 265 (25): 14705–8. PMID 2118515.

[entrez-7] Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3. （原始內容存檔於2010-12-05）.

[8] Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions. Frontiers in Immunology. 2018, 9: 1136. PMC 5978004 . PMID 29881386. doi:10.3389/fimmu.2018.01136.

[pmid10385526-9] Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R. The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. (UNITED STATES). June 1999, 145 (7): 1471–82. ISSN 0021-9525. PMC 2133159 . PMID 10385526. doi:10.1083/jcb.145.7.1471.

[pmid8692885-10] 10.0 ^10.1 Song, H Y; Rothe M; Goeddel D V. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). June 1996, 93 (13): 6721–5. Bibcode:1996PNAS...93.6721S. ISSN 0027-8424. PMC 39093 . PMID 8692885. doi:10.1073/pnas.93.13.6721.

[pmid9928991-11] 11.0 ^11.1 Heyninck, K; Beyaert R. The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett. (NETHERLANDS). January 1999, 442 (2–3): 147–50. ISSN 0014-5793. PMID 9928991. S2CID 19072203. doi:10.1016/S0014-5793(98)01645-7.

[pmid10755617-12] Zhang, S Q; Kovalenko A; Cantarella G; Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity (UNITED STATES). March 2000, 12 (3): 301–11. ISSN 1074-7613. PMID 10755617. doi:10.1016/S1074-7613(00)80183-1.

[pmid10435631-13] De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (ENGLAND). July 1999, 18 (29): 4182–90. ISSN 0950-9232. PMID 10435631. doi:10.1038/sj.onc.1202787 .

[pmid8702721-14] 14.0 ^14.1 ^14.2 Vincenz, C; Dixit V M. 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J. Biol. Chem. (UNITED STATES). August 1996, 271 (33): 20029–34. ISSN 0021-9258. PMID 8702721. doi:10.1074/jbc.271.33.20029 .

[pmid9299557-15] 15.0 ^15.1 De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R. A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins. Biochem. Biophys. Res. Commun. (UNITED STATES). September 1997, 238 (2): 590–4. ISSN 0006-291X. PMID 9299557. doi:10.1006/bbrc.1997.7343.

[pmid11463333-16] Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J. Isolation and characterization of two novel A20-like proteins. Biochem. J. (England). August 2001, 357 (Pt 3): 617–23. ISSN 0264-6021. PMC 1221992 . PMID 11463333. doi:10.1042/0264-6021:3570617.

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