氨柔比星

氨柔比星
临床资料
AHFS/Drugs.com	国际药品名称
给药途径	IV
ATC码	L01DB10 (WHO) ;
法律规范状态
法律规范	处方药（℞-only）;
识别信息
	IUPAC命名法 (7S,9S)-9-Acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; ;
CAS号	110267-81-7
PubChem CID	178149;
ChemSpider	2299344 ;
UNII	93N13LB4Z2;
KEGG	D08854 ;
ChEBI	CHEBI:135779;
ChEMBL	ChEMBL1186894 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID30869526 ;
化学信息
化学式	C25H25NO9
摩尔质量	483.47 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C2c1c(O)c5c(c(O)c1C(=O)c3ccccc23)C[C@](C(=O)C)(N)C[C@@H]5O[C@@H]4OC[C@@H](O)[C@@H](O)C4;
	InChI InChI=1S/C25H25NO9/c1-10(27)25(26)7-13-18(16(8-25)35-17-6-14(28)15(29)9-34-17)24(33)20-19(23(13)32)21(30)11-4-2-3-5-12(11)22(20)31/h2-5,14-17,28-29,32-33H,6-9,26H2,1H3/t14-,15+,16-,17-,25-/m0/s1 ; Key:VJZITPJGSQKZMX-XDPRQOKASA-N ;

氨柔比星（INN：amrubicin；开发代号：SM-5887）是一种用于治疗肺癌的蒽环类药物。^[1]它自2002年起由住友制药以商品名Calsed在日本销售。^[2]

氨柔比星通过抑制拓扑异构酶II发挥作用，并在临床试验中与拓扑替康（拓扑异构酶I抑制剂）进行了比较。^[3]^[4]

它还被研究用于治疗膀胱癌^[5]和胃癌。^[6]

氨柔比星是第一个通过从头合成的蒽环类衍生物，由住友化学家的科学家于1989年首次发表。^[7]

参考资料

^ Ueoka H, Ohnoshi T, Kimura I. [New anthracycline analogues in the treatment of lung cancer]. Gan to Kagaku Ryoho. November 1992, 19 (13): 2146–9. PMID 1332624 （日语）.
^ Sumitomo Pharmaceuticals Co., Ltd. CALSED for Injection (English) (PDF). 2003 [2008-08-17]. ^{[失效链接]}
^ Celgene Corporation. Amrubicin(R) Receives FDA Orphan Drug Designation for the Treatment of Small Cell Lung Cancer. 2008 [2009-07-10]. （原始内容存档于2013-01-19）.
^ Medical News Today. Pharmion's Amrubicin Shows Encouraging Results Compared To Standard Of Care In Second Line Treatment Of Small Cell Lung Cancer. 2007 [2009-07-10]. （原始内容存档于2009-01-03）.
^ Ohmori H, Tsushima T, Kobashi K. [Experimental studies on intravesical instillation of SM-5887, a novel anthracycline derivative for treatment of bladder carcinoma]. Gan to Kagaku Ryoho. April 1996, 23 (5): 601–6. PMID 8678519 （日语）.
^ Tsushima K, Sakata Y, Munakata A, et al. [A phase II study of SM-5887 for advanced gastric cancer]. Gan to Kagaku Ryoho. June 1991, 18 (7): 1151–4. PMID 1647150 （日语）.
^ Hanada M. Amrubicin, Chapter 6 in Case Studies in Modern Drug Discovery and Development. Eds. Huang X and Aslanian RG. John Wiley & Sons, 2012 ISBN 9780470601815 P 106