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合胞素-2

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合胞素-2
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名ERVFRD-1;, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD, endogenous retrovirus group FRD member 1, endogenous retrovirus group FRD member 1, envelope
外部IDOMIM610524 MGI2684898 HomoloGene86779 GeneCardsERVFRD-1
基因位置(人类
6號染色體
染色体6號染色體[1]
6號染色體
合胞素-2的基因位置
合胞素-2的基因位置
基因座6p24.2起始11,102,489 bp[1]
终止11,111,725 bp[1]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_207582

NM_001013751

蛋白序列

NP_997465

NP_001013773

基因位置​(UCSC)Chr 6: 11.1 – 11.11 MbChr 5: 134.59 – 134.59 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

合胞素-2(英語:Syncytin-2,也称为內源性反轉錄病毒FRD组成员1,endogenous retrovirus group FRD member 1),它由ERVFRD-1基因编码[5],与胚胎子宫中的着床有关[6]。該基因是一种内源性病毒元件,它是约4500万年前逆转录病毒感染人類後的残余物[7]

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000244476 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000085957 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Entrez Gene: HERV-FRD HERV-FRD provirus ancestral Env polyprotein. 
  6. ^ Vargas A, Moreau J, Landry S, LeBellego F, Toufaily C, Rassart E, Lafond J, Barbeau B. Syncytin-2 plays an important role in the fusion of human trophoblast cells. Journal of Molecular Biology. 2009, 392 (2): 301–18. PMID 19616006. doi:10.1016/j.jmb.2009.07.025. 
  7. ^ Lavialle C, Cornelis G, Dupressoir A, Esnault C, Heidmann O, Vernochet C, Heidmann T. Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. September 2013, 368 (1626): 20120507. PMC 3758191可免费查阅. PMID 23938756. doi:10.1098/rstb.2012.0507. 

外部鏈接