受體酪氨酸激酶 (receptor tyrosine kinases,RTKs)為對多種多肽 類生長因子 、細胞因子 ,及激素 具有高親和性 細胞表面受體 。人類 目前已知約有90種酪氨酸激酶 基因 ,其中有59個基因會轉譯出受體酪氨酸激酶[ 1] 。
除了正常的生理功能之外,此類蛋白也在許多類癌細胞 的發育和調控上扮演重要角色[ 2] 。此類基因的變異會活化許多一系列級聯反應,影響蛋白質的表現[ 3] 。受體酪氨酸激酶為酪氨酸激酶 中較大的一個蛋白質家族,此類蛋白的特點是具有疏水性的穿膜區,反之其他類的酪氨酸激酶 則沒有穿膜區[ 4] 。
命名
受體酪氨酸激酶(receptor tyrosine kinase,RTK)有時也會被稱為酪氨酸受體激酶 (tyrosine receptor kinase,TRK,Trk)或酪氨酸激酶受體 (tyrosine kinase receptor,TKR)。
類別
目前已知約有20[ 5] 。
參考文獻
^ Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene. November 2000, 19 (49): 5548–57. PMID 11114734 . doi:10.1038/sj.onc.1203957 .
^ Zwick E, Bange J, Ullrich A. Receptor tyrosine kinase signalling as a target for cancer intervention strategies. Endocrine-Related Cancer. September 2001, 8 (3): 161–73. PMID 11566607 . doi:10.1677/erc.0.0080161 .
^ Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases . Cell. June 2010, 141 (7): 1117–34. PMC 2914105 . PMID 20602996 . doi:10.1016/j.cell.2010.06.011 .
^ Hubbard SR, Till JH. Protein tyrosine kinase structure and function. Annual Review of Biochemistry. 2000, 69 ( ): 373–98. PMID 10966463 . doi:10.1146/annurev.biochem.69.1.373 .
^ Ségaliny et al. (2015) "Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers". Bone Oncology 23;4 (1):1-12.[1] (页面存档备份 ,存于互联网档案馆 ) Retrieved on 2017-09-17
外部連結
血管生成素 CNTF EGF (ErbB)
FGF
FGFR1 FGFR2
受體激動劑: Ersofermin
FGF (1 , 2 (bFGF) , 3 , 4 , 5 , 6 , 7 (KGF ), 8 , 9 , 10 (KGF2) , 17 , 18 , 22 )
Palifermin
Repifermin
Sprifermin
Trafermin
FGFR3 FGFR4 Unsorted
HGF (c-Met) IGF
LNGF (p75NTR ) PDGF RET (GFL)
SCF (c-Kit) TGFβ Trk
TrkA
Negative allosteric modulators: VM-902A
TrkB
受體激動劑: 3,7-DHF
3,7,8,2'-THF
4'-DMA-7,8-DHF
7,3'-DHF
7,8-DHF
7,8,2'-THF
7,8,3'-THF
阿米替林
BDNF
BNN-20
Deoxygedunin
Deprenyl
Diosmetin
DMAQ-B1
HIOC
LM22A-4
N-乙酰血清素
NT-3
NT-4
Norwogonin (5,7,8-THF)
R7
TDP6
TrkC
VEGF 其他
Additional growth factors: Adrenomedullin
Colony-stimulating factor s (see here instead)
Connective tissue growth factor (CTGF)
Ephrin s (A1 , A2 , A3 , A4 , A5 , B1 , B2 , B3 )
紅血球生成素 (see here instead)
葡萄糖-6-磷酸異構酶 (GPI; PGI, PHI, AMF)
Glia maturation factor (GMF)
Hepatoma-derived growth factor (HDGF)
白细胞介素 /T-cell growth factor s (see here instead)
白血病抑制因子 (LIF)
Macrophage-stimulating protein (MSP; HLP, HGFLP)
Midkine (NEGF2)
Migration-stimulating factor (MSF; PRG4)
Oncomodulin
Pituitary adenylate cyclase-activating peptide (PACAP)
Pleiotrophin
Renalase
促血小板生成素 (see here instead)
Wnt信号通路
Additional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)