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C-Myc

本页使用了标题或全文手工转换
维基百科，自由的百科全书
c-Myc
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名MYC；, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog, MYC proto-oncogene, bHLH transcription factor, Genes, myc, c-myc
外部IDOMIM：190080 MGI：97250 HomoloGene：31092 GeneCards：MYC
基因位置（人类）
8號染色體
染色体8號染色體[1]
8號染色體
c-Myc的基因位置
c-Myc的基因位置
基因座8q24.21起始127,735,434 bp[1]
终止127,742,951 bp[1]
直系同源
物種人類小鼠
Entrez

4609

17869

Ensembl

ENSG00000136997

ENSMUSG00000022346

UniProt

P01106

P01108

mRNA​序列

NM_002467
​NM_001354870

NM_001177352
​NM_001177353
​NM_001177354
​NM_010849

蛋白序列

NP_002458
​NP_001341799

NP_001170823
​NP_001170824
​NP_001170825
​NP_034979

基因位置​（UCSC）Chr 8: 127.74 – 127.74 MbChr 15: 61.86 – 61.86 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

C-Myc或Myc是编码转录因子的调节基因。这一基因编码的蛋白在细胞核内被磷酸化，有多种功能：在细胞周期进程、细胞凋亡和细胞轉化中发挥作用。[5]

相互作用

Myc可与以下蛋白质发生交互作用：

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000136997 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000022346 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Myc myelocytomatosis oncogene [ Mus musculus (house mouse) ]. [2018-03-02]. （原始内容存档于2019-05-11）. 
  6. ^ 6.0 6.1 6.2 6.3 Park J, Wood MA, Cole MD. BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Molecular and Cellular Biology. March 2002, 22 (5): 1307–16. PMC 134713 可免费查阅. PMID 11839798. doi:10.1128/mcb.22.5.1307-1316.2002. 
  7. ^ 7.0 7.1 Li H, Lee TH, Avraham H. A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. The Journal of Biological Chemistry. June 2002, 277 (23): 20965–73. PMID 11916966. doi:10.1074/jbc.M112231200. 
  8. ^ Xiong J, Fan S, Meng Q, Schramm L, Wang C, Bouzahza B, Zhou J, Zafonte B, Goldberg ID, Haddad BR, Pestell RG, Rosen EM. BRCA1 inhibition of telomerase activity in cultured cells. Molecular and Cellular Biology. December 2003, 23 (23): 8668–90. PMC 262673 可免费查阅. PMID 14612409. doi:10.1128/mcb.23.23.8668-8690.2003. 
  9. ^ Zhou C, Liu J. Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells. Biochemical and Biophysical Research Communications. March 2003, 303 (1): 130–6. PMID 12646176. doi:10.1016/s0006-291x(03)00318-8. 
  10. ^ Wang Q, Zhang H, Kajino K, Greene MI. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene. October 1998, 17 (15): 1939–48. PMID 9788437. doi:10.1038/sj.onc.1202403. 
  11. ^ 11.0 11.1 Jin Z, Gao F, Flagg T, Deng X. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. The Journal of Biological Chemistry. September 2004, 279 (38): 40209–19. PMID 15210690. doi:10.1074/jbc.M404056200. 
  12. ^ Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM. c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. Oncogene. August 2003, 22 (36): 5707–11. PMID 12944920. doi:10.1038/sj.onc.1206800. 
  13. ^ Dingar D, Kalkat M, Chan PK, Srikumar T, Bailey SD, Tu WB, Coyaud E, Ponzielli R, Kolyar M, Jurisica I, Huang A, Lupien M, Penn LZ, Raught B. BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors. Journal of Proteomics. April 2015, 118 (12): 95–111. PMID 25452129. doi:10.1016/j.jprot.2014.09.029. 
  14. ^ Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, Pelicci PG, Amati B, Kouzarides T, de Launoit Y, Di Croce L, Fuks F. Myc represses transcription through recruitment of DNA methyltransferase corepressor. The EMBO Journal. January 2005, 24 (2): 336–46. PMC 545804 可免费查阅. PMID 15616584. doi:10.1038/sj.emboj.7600509. 
  15. ^ 15.0 15.1 Fuchs M, Gerber J, Drapkin R, Sif S, Ikura T, Ogryzko V, Lane WS, Nakatani Y, Livingston DM. The p400 complex is an essential E1A transformation target. Cell. August 2001, 106 (3): 297–307. PMID 11509179. doi:10.1016/s0092-8674(01)00450-0. 
  16. ^ Roy AL, Carruthers C, Gutjahr T, Roeder RG. Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature. September 1993, 365 (6444): 359–61. PMID 8377829. doi:10.1038/365359a0. 
  17. ^ Frank SR, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan HM, Livingston DM, Amati B. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Reports. June 2003, 4 (6): 575–80. PMC 1319201 可免费查阅. PMID 12776177. doi:10.1038/sj.embor.embor861. 
  18. ^ Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT. Widespread microRNA repression by Myc contributes to tumorigenesis. Nature Genetics. January 2008, 40 (1): 43–50. PMC 2628762 可免费查阅. PMID 18066065. doi:10.1038/ng.2007.30. 
  19. ^ Koscianska E, Baev V, Skreka K, Oikonomaki K, Rusinov V, Tabler M, Kalantidis K. Prediction and preliminary validation of oncogene regulation by miRNAs. BMC Molecular Biology. 2007, 8: 79. PMC 2096627 可免费查阅. PMID 17877811. doi:10.1186/1471-2199-8-79. 
  20. ^ Ioannidis P, Mahaira LG, Perez SA, Gritzapis AD, Sotiropoulou PA, Kavalakis GJ, Antsaklis AI, Baxevanis CN, Papamichail M. CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells. The Journal of Biological Chemistry. May 2005, 280 (20): 20086–93. PMID 15769738. doi:10.1074/jbc.M410036200. 
  21. ^ Gupta S, Davis RJ. MAP kinase binds to the NH2-terminal activation domain of c-Myc. FEBS Letters. October 1994, 353 (3): 281–5. PMID 7957875. doi:10.1016/0014-5793(94)01052-8. 
  22. ^ Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proceedings of the National Academy of Sciences of the United States of America. July 1997, 94 (14): 7337–42. PMC 23822 可免费查阅. PMID 9207092. doi:10.1073/pnas.94.14.7337. 
  23. ^ Noguchi K, Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y. Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase. The Journal of Biological Chemistry. November 1999, 274 (46): 32580–7. PMID 10551811. doi:10.1074/jbc.274.46.32580. 
  24. ^ 24.0 24.1 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular Systems Biology. 2007, 3: 89. PMC 1847948 可免费查阅. PMID 17353931. doi:10.1038/msb4100134. 
  25. ^ 25.0 25.1 McMahon SB, Wood MA, Cole MD. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Molecular and Cellular Biology. January 2000, 20 (2): 556–62. PMC 85131 可免费查阅. PMID 10611234. doi:10.1128/mcb.20.2.556-562.2000. 
  26. ^ 26.0 26.1 McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell. August 1998, 94 (3): 363–74. PMID 9708738. doi:10.1016/s0092-8674(00)81479-8. 
  27. ^ 27.0 27.1 Cheng SW, Davies KP, Yung E, Beltran RJ, Yu J, Kalpana GV. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. Nature Genetics. May 1999, 22 (1): 102–5. PMID 10319872. doi:10.1038/8811. 
  28. ^ 28.0 28.1 Mac Partlin M, Homer E, Robinson H, McCormick CJ, Crouch DH, Durant ST, Matheson EC, Hall AG, Gillespie DA, Brown R. Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX. Oncogene. February 2003, 22 (6): 819–25. PMID 12584560. doi:10.1038/sj.onc.1206252. 
  29. ^ Blackwood EM, Eisenman RN. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. March 1991, 251 (4998): 1211–7. PMID 2006410. doi:10.1126/science.2006410. 
  30. ^ Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proceedings of the National Academy of Sciences of the United States of America. October 2002, 99 (22): 14189–94. PMC 137859 可免费查阅. PMID 12391307. doi:10.1073/pnas.232310199. 
  31. ^ Billin AN, Eilers AL, Queva C, Ayer DE. Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. The Journal of Biological Chemistry. December 1999, 274 (51): 36344–50. PMID 10593926. doi:10.1074/jbc.274.51.36344. 
  32. ^ Gupta K, Anand G, Yin X, Grove L, Prochownik EV. Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. Oncogene. March 1998, 16 (9): 1149–59. PMID 9528857. doi:10.1038/sj.onc.1201634. 
  33. ^ Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. The EMBO Journal. May 1997, 16 (10): 2892–906. PMC 1169897 可免费查阅. PMID 9184233. doi:10.1093/emboj/16.10.2892. 
  34. ^ Nair SK, Burley SK. X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Cell. January 2003, 112 (2): 193–205. PMID 12553908. doi:10.1016/s0092-8674(02)01284-9. 
  35. ^ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE. Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. Oncogene. April 1999, 18 (15): 2489–98. PMID 10229200. doi:10.1038/sj.onc.1202611. 
  36. ^ Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A. Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?. Oncogene. July 2000, 19 (29): 3266–77. PMID 10918583. doi:10.1038/sj.onc.1203634. 
  37. ^ Guo Q, Xie J, Dang CV, Liu ET, Bishop JM. Identification of a large Myc-binding protein that contains RCC1-like repeats. Proceedings of the National Academy of Sciences of the United States of America. August 1998, 95 (16): 9172–7. PMC 21311 可免费查阅. PMID 9689053. doi:10.1073/pnas.95.16.9172. 
  38. ^ Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC. Genes to Cells. August 1998, 3 (8): 549–65. PMID 9797456. doi:10.1046/j.1365-2443.1998.00206.x. 
  39. ^ Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K. Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. Journal of Cell Science. April 2001, 114 (Pt 8): 1533–44. PMID 11282029. 
  40. ^ Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H. Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. The Journal of Biological Chemistry. August 1999, 274 (34): 24270–9. PMID 10446203. doi:10.1074/jbc.274.34.24270. 
  41. ^ Uramoto H, Izumi H, Ise T, Tada M, Uchiumi T, Kuwano M, Yasumoto K, Funa K, Kohno K. p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression. The Journal of Biological Chemistry. August 2002, 277 (35): 31694–702. PMID 12080043. doi:10.1074/jbc.M200266200. 
  42. ^ 42.0 42.1 42.2 42.3 42.4 42.5 Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E. c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation. The Journal of Biological Chemistry. May 2003, 278 (22): 20405–12. PMC 4031917 可免费查阅. PMID 12660246. doi:10.1074/jbc.M211795200. 
  43. ^ Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H. MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc. The Journal of Biological Chemistry. November 1998, 273 (45): 29794–800. PMID 9792694. doi:10.1074/jbc.273.45.29794. 
  44. ^ Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H. MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer. The Journal of Biological Chemistry. November 2001, 276 (48): 45137–44. PMID 11567024. doi:10.1074/jbc.M106127200. 
  45. ^ 45.0 45.1 Feng XH, Liang YY, Liang M, Zhai W, Lin X. Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B). Molecular Cell. January 2002, 9 (1): 133–43. PMID 11804592. doi:10.1016/s1097-2765(01)00430-0. 
  46. ^ Otsuki Y, Tanaka M, Kamo T, Kitanaka C, Kuchino Y, Sugimura H. Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts. The Journal of Biological Chemistry. February 2003, 278 (7): 5132–40. PMID 12446731. doi:10.1074/jbc.M206733200. 
  47. ^ Damerell V, Ambele MA, Salisbury S, Neumann-Mufweba A, Durandt C, Pepper MS, Prince S. The c-Myc/TBX3 Axis Promotes Cellular Transformation of Sarcoma-Initiating Cells. Frontiers in oncology. Jan 2022, 11 (80): 1691 [2022-06-28]. PMC 8821881 可免费查阅. PMID 35145908. doi:10.3389/fonc.2021.801691. （原始内容存档于2022-06-28）. 
  48. ^ Gaubatz S, Imhof A, Dosch R, Werner O, Mitchell P, Buettner R, Eilers M. Transcriptional activation by Myc is under negative control by the transcription factor AP-2. The EMBO Journal. April 1995, 14 (7): 1508–19. PMC 398238 可免费查阅. PMID 7729426. 
  49. ^ Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP. Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. Molecular Cell. May 2015, 58 (3): 440–52. PMC 4427524 可免费查阅. PMID 25818646. doi:10.1016/j.molcel.2015.02.028. 
  50. ^ Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science. December 1993, 262 (5141): 1889–92. PMID 8266081. doi:10.1126/science.8266081. 
  51. ^ Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M. Repression of p15INK4b expression by Myc through association with Miz-1. Nature Cell Biology. April 2001, 3 (4): 392–9. PMID 11283613. doi:10.1038/35070076. 
  52. ^ Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M. An alternative pathway for gene regulation by Myc. The EMBO Journal. September 1997, 16 (18): 5672–86. PMC 1170199 可免费查阅. PMID 9312026. doi:10.1093/emboj/16.18.5672. 
检索自“https://zh.wikipedia.org/w/index.php?title=C-Myc&oldid=73521727”